Autoimmune Disease

The immune system is connected to nearly every organ and tissue in the human body and most people don’t realize that nearly every disease is impacted by immune dysfunction. One of the immune system’s main functions is to protect the body from attack of foreign invaders including viruses, bacteria, mold, and toxins [1]. The capacity to distinguish between “self” and non-self” substances plays a central role in the process of immunity [2,3]. All autoimmune disorders are the result of the breakdown of this “self”-tolerance, where the body starts attacking its own healthy tissues [4]. 

Approximately 50 million Americans, or 20% of the population, live with an autoimmune disease. Autoimmune diseases are caused by our own immune system recognizing something, whether it be an organ, tissue, cells, etc., as foreign and targeting it for destruction. This causes very serious complications, disabilities, and in many cases, eventual death. 

What problem do patients face?

There are 80-100 different types of autoimmune diseases, the majority of which become debilitating over time and impact quality of life. There is no cure for these diseases, and while there are many drugs available, many patients are non-respondent these drugs. The pharmacological options for autoimmune disorders are mainly based on immunosuppressive activities that minimize or delay cellular damages in the affected organs rather than regulating or controlling the autoimmune process [2,5]. Hence, there are no drugs available to regulate the immune system in the market, and the immunosuppressive drugs available are associated with serious side effects.   

What is the solution?

Studies have proven the significant potential of mesenchymal stem cells (MSCs) in treating autoimmune disorders. MSCs can be used as a natural and effective form of treatment to regulate the immune system based on their unique properties. The average human body has a strong army of T cells, or soldiers, that track down and destroy any invaders within the body. A human body affected by autoimmune disorders, on the other hand, has a weak defense system and is constantly being attacked by its own army.  MSCs have the remarkable ability to secrete molecules that increase the number of soldiers traveling through the body, creating a stronger defense. The molecules MSCs secrete also have the added benefit of tracking down cells that could potentially harm naïve T cells, or “soldiers in training”. The dynamic secretion pattern and powerful ability to regulate immune activity make these cells a phenomenal candidate for the treatment of many different autoimmune diseases. 

Our precision Mesenchymal Stem Cell Therapy enables the immune system to halt pathological responses, all while preserving its ability to fight disease. In essence, our therapeutic approach drastically reduces a patient’s inflammatory markers, returning the body’s immune system to a stronger, more healthy state. After our MSC therapy, most patients experience: 

  • Noticeable improvement in their primary complaint
  • Less frequent and less severe illnesses
  • Quicker healing and recovery
  • Decreased pain and discomfort
  • Improved functionality, mobility, and sleep quality
  • Significant overall improvement of mental and physical wellbeing 

These effects may last for years following treatment. Most importantly, no serious adverse effects have been reported following this therapeutic approach. 

Hear about a real patient’s experience with REHEALTH

“I’ve seen more improvement in the last year in my healing process than I had in the previous 4-5 years. Undeniable. Overall improvement in energy levels, pain levels, deep sleep levels – pretty much everything across the board. A reduction in frailty from years of being sick.

I’m really happy with the results. It’s been great.” 

CameronStem Cell Therapy – Lupus

See if REHEALTH is Right for You

At REHEALTH, our mission is to improve patient health and well-being through precision stem cell therapeutics. Our team of certified physicians will work with you to design a personalized therapeutic approach to target your specific needs. 

Join thousands of other patients who have experienced relief they never thought was possible. Schedule a free discovery call and start your journey to recovery today.

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References

  1. Haque N, Ramasamy TS, Kasim NHA. Mechanisms of mesenchymal stem cells for autoimmune disease treatment. In: Pham P. (eds). Stem cell transplantation for autoimmune diseases and inflammation. Stem Cells in Clinical Applications. Springer, Cham. 2019.
  2. Rioux JD, Abbas AK. Paths to understanding the genetic basis of autoimmune disease. Nature. 2005. 435:584.
  3. Yang SH, Gao CY, li L, Chang C, et al. The molecular basis of immune regulation in autoimmunity. Clin Sci. 2018. 132(1):43-67.
  4. Rosenblum MD, Remedios KA, Abbas AK. Mechanisms of human autoimmunity. J Clin Invest. 2015. 125(6):2228-33.
  5. Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: a review: Indian J Pharmacol. 2012. 44(6):665-71.}
  6. Gao F, Chiu SM, Motan DAL, et al. Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis. 2016. 7:e2062.
  7. Kimbrel EA, Kouris NA, Yavanian GJ, et al. Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties. Stem Cells Dev. 2014. 23(14):1611-24.
  8. Ganguly D, Haak S, Sisirak V, Reizis B. The role of dendritic cells in autoimmunity. Nat Rev Immunol. 2013. 13(8):566-77.
  9. Sozzani S, Del Prete A, Bosisio D. Dendritic cell recruitment and activation in autoimmunity. J Autoimmun. 2017. 85:126-40.
  10. Gebler A, Zabel O, Seliger. The immunomodulatory capacity of mesenchymal stem cells. Trends Mol Ther. 2012. 20(1):187-95.
  11. Shlomchik MJ. Activating systemic autoimmunity: B’s, T’s and tolls. Curr Opin Immunol. 2009. 21(6):626-33.
  12. Summers SA, Hoi A, Steinmetz OM, et al. TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in primate nephropaty. J Autoimmun. 2010. 35(4):291-8.
  13. Flodstrom-Tullberg M, Bryceson YT, Shi FD, Hoglund P, Ljunggren HG. Natural killer cells in human autoimmunity. Curr Opin Immunol. 2009. 21(6). 634-40.
  14. Fogel LA, Yokoyama WM, French AR. Natural killer cells in human autoimmune disorders. Arthritis Res Ther. 2013. 15(4):216.