Stem cells release an antiinflammatory microenvironment around them that influences the behavior of neighboring cells, promoting tissue regeneration and improving muscle function.
Clinical studies with stem cells have shown an improved ventricular remodeling and cardiac metabolism, which translates into a better quality of life conditions.
Stem cells secrete angiogenic factors, which promote the formation of new blood vessels from pre-existing ones in a very similar way to a sprout and splitting behavior. Conditions with poor vascularization may benefit from stem cell therapy by promoting the creation of a more developed circulatory network.
The regenerative properties of stem cells, such as increased energy efficiency and immune modulation, promote better functioning conditions. If your body is physically better, you’ll feel better too!
A typical human myocardial infarct involves the loss of approximately 1 billion cardiomyocytes and 2–3 billion other (mostly endothelial) myocardial cells, leading to a significant negative impact on the length and quality of life[1,21,22].
Although mesenchymal stem cells (MSCs) can change into different cell types, including cardiomyocytes and endothelial cells, this is not their primary mechanism of action in cardiovascular regeneration. MSCs release an antiinflammatory microenvironment around them that influences the behavior of neighboring cells[3,4], such as endogenous stem cell recruitment, proliferation, and cell change and most importantly neovascularization (increase blood flow)[5-15].
MSCs secrete various molecules that induce cardioprotection by stopping cell death and increasing angiogenesis, a process that significantly increases blood flow to vital tissues [16-19,25]. Also, MSCs stimulate the proliferation and change of endogenous cardiac stem cells, thus contributing to muscle regeneration. These properties have been shown by the improvement of the left ventricular remodeling and cardiac metabolism following MSC therapy.
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