Stem Cell Therapy

The human body strives to maintain a constant state of homeostasis in order to remain healthy. When tissue and cells within the body become damaged, stem cells act quickly to target the damaged area and initiate repair. Stem cells are the incredible cells from which all other cells with specialized functions in the human body are generated. They are undifferentiated cells that have the capacity to duplicate indefinitely and change into various cell types depending on the body’s need1,5.

When stem cells divide, they produce daughter cells, which can then either become new stem cells (known as self-renewal) or can become specialized cells (known as differentiation) with a more specific function1. These unique daughter cells are the only cells in the body that have the ability to generate new cell types, and can differentiate into blood cells, brain cells, heart muscle cells, or bone cells. Whether grown up in the body or in the lab, stem cells have incredible regenerative and healing properties that can improve numerous conditions. 

Each type of specialized cell has unique characteristic shapes, structures, and functions depending on their function and location. Studies have shown that stem cells can obtain signals and cues from distressed cells throughout the body, then use these signals to differentiate depending on which area of the body needs repair. Additionally, stem cells can also control the immune system (immune modulation) and increase blood flow (angiogenesis) to help heal and repair the entire system4,5. 

Each time our cells divide, our telomeres become shorter. As we age, cells start to have ‘critically short telomeres’, and at some point, cells stop dividing altogether and become senescent. Cells produce telomerase to stop shortening of telomeres. As seen in the graphs, ULSCs have much higher telomere length and much higher telomerase activity than adipose and bone marrow SC. This data suggests at a cellular level how youthful ULSCs are.

Mesenchymal stem cells (MSCs) are cells that can be isolated from bone marrow, adipose tissue, dental pulp, placenta, and much more2. Our research team utilizes our proprietary method to isolate and grow these cells from umbilical cord tissue to yield umbilical cord lining stem cells (ULSCs). We use these allogeneic cells from umbilical cord tissue because they are the youngest and most vibrant source. While adult stem cells have the potential to carry diseases transmitted throughout adulthood, scientific studies have shown that allogenic young cells like those isolated from umbilical cord tissue are more potent and more efficient.

Young, vibrant ULSCs
Older, less vibrant bone marrow SC

With patient safety in mind, we also prescreen our donors for genetic abnormalities, viruses, and bacteria. REHEALTH prioritizes patient safety and efficacy from the lab to the clinic. Discover the potential of REHEALTH’s proprietary stem cell therapy and reclaim your health today.

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Our mission is to improve patient health and well-being through precision stem cell therapeutics. Our team of certified physicians will work with you to design a personalized therapeutic approach to target your specific needs. 

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References

  1. Gonzalez et al. Stem Cells Targeting Inflammation as Potential Anti-aging Strategies and Therapies. Cell & Tissue Transplantation & Therapy 2015:7 1–8 doi:10.4137/CTTT.S19477.
  2. Gonzalez R, Griparic L, Umana M, et al. An Efficient Approach to Isolation and Characterization of Pre- and Postnatal Umbilical Cord Lining Stem Cells for Clinical Applications. Cell Transplantation. 2010;19(11):1439-1449. doi:10.3727/096368910X514260
  3. Wang D, Zhang H, Cao M, Tang Y, Liang J, Feng X, Wang H, Hua B, Liu B, Sun L. Efficacy of allogeneic mesenchymal stem cell transplantation in patients with drug-resistant polymyositis and dermatomyositis. Ann Rheum Dis. 2011 Jul;70(7):1285-8. doi: 10.1136/ard.2010.141804. PMID: 21622775.
  4. Cao N, Liao T, Liu J, Fan Z, Zeng Q, Zhou J, Pei H, Xi J, He L, Chen L, Nan X, Jia Y, Yue W, Pei X. Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis. Cell Death Dis. 2017 Aug 10;8(8):e2996. doi: 10.1038/cddis.2017.316. PMID: 28796260; PMCID: PMC5596535.
  5. El Omar R, Beroud J, Stoltz JF, Menu P, Velot E, Decot V. Umbilical cord mesenchymal stem cells: the new gold standard for mesenchymal stem cell-based therapies? Tissue Eng Part B Rev. 2014 Oct;20(5):523-44. doi: 10.1089/ten.TEB.2013.0664. Epub 2014 Apr 22. PMID: 24552279.